by Mark Lipton » Sun Oct 04, 2009 10:39 pm
I haven't read Luca Turin's book, but I have read a fairly extensive critique of that book, and the theories that are expounded therein, in the journal Science some years ago. I suppose that Mr. Yarrow would have to count me among that "scientific establishment" that dismisses Mr. Turin's ideas. One aspect of my critique: Mr. Yarrow uses the reported number of olfactory receptors (347) as an argument why there can't be a one molecule-one receptor correlation for smell, but that's been widely discredited for generations now. Instead, starting with just 347 receptors and assuming a binary (on/off) response, one can still posit 347! possible outputs, far more than is needed to characterize all of the smells that we are likely to be exposed to in a lifetime. What we know about those receptors is that they are fairly low affinity (as opposed to e.g. antibodies that have high affinity and strict specificity for one antigen) but broadly responsive, so that many different molecules may activate a given receptor, albeit to differing degrees (thereby expanding that initial figure of 347! to a far larger number). In fact, a friend at UT Austin has made a career out of developing a "molecular nose" that works in exactly the same way, using an array of low affinity receptors and applying sophisticated processing to their output.
Mark Lipton